First ERNEST Training School - June 15/16, 2021
​Computational Tools to Study GPCR Signaling:
From the Genomic to the Systems Level
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The ERNEST Training School is dedicated specifically to the Mapping Group.
Event runs on Central European Summer Time (CEST).
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All sessions and rooms are passcode-protected. Registrants receive their access info by email.
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Registration closed.
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PROGRAMME
Day 1: June 15, 2021
9:45 AM - 10:00 AM CEST Welcome & Opening
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Host: Jana Selent & Co-Host: Martha Sommer
10:00 AM - 12:00 PM CEST
Hands-On Session 1: Genomics Level
Presenter: Maria Marti Solano
We will explore genomics information on variants and polymorphisms which could impact receptor physiology and drug response. We will start to assess how these variants could influence receptor structure and function.
12:30 PM - 13:30 PM CEST
Seminar: From 3D Structure to Function via Energy Functions
Presenter: Mickey Kosloff
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We will explore how one can use 3D structures in different structural bioinformatics approaches. The concept of energy functions will be introduced, with emphasis on molecular dynamics. Additional approaches will be covered, such as knowledge-based approaches or other physics-based methods.
13:30 PM - 14:30 PM CEST Lunch Break
14:30 PM - 16:30 PM CEST
Hands-On Session 2: Structural Level
Presenter: Jana Selent
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We will map information about polymorphisms obtained from the genomics level on a three-dimensional structure and probe their impact on receptor dynamics and ligand binding using molecular dynamics simulations.
16:30 PM - 18:00 PM Virtual Happy Hour
Meet Us in the Networking Room for Socializing Activities
Day 2: June 16, 2021
9:00 AM - 11:00 AM CEST Hands-On Session 3: Systems Level
Presenter: Maria Krantz
We will focus on the impact of particular polymorphisms at a systems level by using a simplified model of a GPCR signalling system integrating different receptor signaling parameters. This model will allow simulating how polymorphisms affect these different parameters to alter receptor function.
11:00 AM - 11:30 AM CEST Coffee Break
Meet your friends in the Networking Room
11:30 AM - 13:30 PM CEST
Hands-On Session 4: Data Level
Presenters: Ulrike Wittig and Maja Rey
We will provide a general overview about data management including storage, sharing, interlinking, publishing, and curation of scientific data. This will allow developing a framework to integrate data generated in session 1, 2 and 3.
13:30 PM - 14:00 PM CEST Summary & Closing
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Host: Jana Selent
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SPEAKERS and HOSTS
Host: Jana Selent - Vice Chair of CA18133 ERNEST
Pompeu Fabra University, Barcelona, Spain
Co-Host: Martha Sommer - Chair of CA18133 ERNEST Charité Medical University, Berlin, Germany
Max Delbrück Center for Molecular Medicine, Berlin, Germany
Presenter: Maja Rey
Heidelberg Institute for Theoretical Studies, Germany
Presenter: Mickey Kosloff
Department of Human Biology, University of Haifa, Israel
Presenter: Maria Marti Solano
MRC Laboratory of Molecular Biology, Cambridge, UK
Presenter: Maria Krantz
Theoretical Biophysics, Humboldt University, Berlin, Germany
Presenter: Ulrike Wittig
Heidelberg Institute for Theoretical Studies, Germany
ZOOM HOSTS & TECH SUPPORT
Luise Wagner, ICTAC
Tony Auth, ICTAC